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• Abuse. Past physical, sexual, or emotional abuse can cause depression later in life.
• Certain medications. For example, some drugs used to treat high blood pressure, such as beta-blockers or reserpine, can increase your risk of depression.
• Conflict. Depression may result from personal conflicts or disputes with family members or friends.
• Death or a loss. Sadness or grief from the death or loss of a loved one, though natural, can also increase the risk of depression.
• Genetics. A family history of depression may increase the risk. It’s thought that depression is passed genetically from one generation to the next. The exact way this happens, though, is not known.
• Major events. Even good events such as starting a new job, graduating, or getting married can lead to depression. So can moving, losing a job or income, getting divorced, or retiring.
• Other personal problems. Problems such as social isolation due to other mental illnesses or being cast out of a family or social group can lead to depression.
• Serious illnesses. Sometimes depression co-exists with a major illness or is a reaction to the illness.
• Substance abuse. Nearly 30% of people with substance abuse problems also have major or clinical depression.